I work at the crossing of computer science and genetics/genomics.
I'm currently in my final year as a Ph.D. student at the University of Liège, where I carry my research at the Unit of Human Genetics of the GIGA research center. I'm advised by Prof. Vincent Bours and Prof. Guy Jerusalem and my work is funded by an FRS-FNRS fellowship.
I apply machine learning, algorithmics, and software engineering methods to genomics data arising from cancer related questions.
As the modern genomic and transcriptomic techniques yield vast amounts of data, machine learning methods are well suited to tackle problems taking roots in these fields.
My research projects have led me to work with exome and transcriptome (RNA) sequencing data, as well as aCGH. I was particularly interested in the integration of these different techniques in human cancer samples, and how the consequent emergent information would give a better understanding of the sample specificities.
I've had the opportunity to work on projects related to the clinical (non-invasive diagnosis), technical (CNV detection), and molecular (non-coding RNAs) aspects of cancer.
My activities have led me to work both in a research and a clinical setting, often building bridges between both.
Exome Copy Number Variation detection: use of a pool of unrelated healthy tissue as reference sample.
Stephane Wenric*, Tiberio Sticca*, Jean-Hubert Caberg, Claire Josse, Corinne Fasquelle, Christian Herens, Mauricette Jamar, Stéphanie Max, André Gothot, Jo Caers, Vincent Bours.*: as co-first authors
Genetic Epidemiology. 2016
Genomic Studies of Multiple Myeloma Reveal an Association between X Chromosome Alterations and Genomic Profile Complexity.
Tiberio Sticca, Jean‐Hubert Caberg, Stephane Wenric, Christophe Poulet, Christian Herens, Mauricette Jamar, Claire Josse, Sonia El Guendi, Stéphanie Max, Yves Beguin, André Gothot, Jo Caers, Vincent Bours
Genes, Chromosomes and Cancer. 2016
Circulating microRNA-based screening tool for breast cancer.
Pierre Frères*, Stéphane Wenric*, Meriem Boukerroucha, Corinne Fasquelle, Jérôme Thiry, Nicolas Bovy, Ingrid Struman, Pierre Geurts, Joëlle Collignon, Hélène Schroeder, Frédéric Kridelka, Eric Lifrange, Véronique Jossa, Vincent Bours, Claire Josse, Guy Jerusalem *: as co-first authors
Oncotarget. 2015
Evaluation of BRCA1-related molecular features and microRNAs as prognostic factors for triple negative breast cancers.
Meriem Boukerroucha, Claire Josse, Sonia El Guendi, Bouchra Boujemla, Pierre Frères, Raphaël Marée, Stephane Wenric, Karin Segers, Joelle Collignon, Guy Jerusalem, Vincent Bours
BMC cancer. 2015
Transcriptome wide analysis of natural antisense transcripts shows their potential role in breast cancer.
Stephane Wenric, Sonia El Guendi, Jean-Hubert Caberg, Warda Bezzaou, Corinne Fasquelle, Benoit Charloteaux, Latifa Karim, Benoit Hennuy, Pierre Frères, Joëlle Collignon, Meriem Boukerroucha, Hélène Schroeder, Fabrice Olivier, Véronique Jossa, Guy Jerusalem, Vincent Bours and Claire Josse.
Submitted to Cancer Research. 2017
Whole exome sequencing in Rwandan patients with neurodevelopmental disorders
Annette Uwineza, Jean-Hubert Caberg, Janvier Hitayezu, Janvier Ndinkabandi, Seraphine Murorunkwere, Mauricette Jamar, Cecile Libioulle, Vinciane Dideberg, Corinne Fasquelle, Stephane Wenric, François Guillaume Debray, Vincent Bours, Leon Mutesa.
Submitted to Journal of Neurodevelopmental Disorders. 2016
Variations of circulating biomarkers during and after anthracycline-containing chemotherapy in breast cancer patients
Pierre Frères, Nassim Bouznad, Laurence Servais, Claire Josse, Stephane Wenric, Aurélie Poncin, Jérôme Thiry, Marie Moonen, Cécile Oury, Patrizio Lancellotti, Vincent Bours, Guy Jerusalem.
Submitted to BMC Cancer. 2016
Method for the diagnosis of breast cancer.
European Patent EP2942399. 2015
Transcriptome wide analysis of natural antisense transcripts shows their potential role in breast cancer.
Stephane Wenric, Sonia El Guendi, Jean-Hubert Caberg, Warda Bezzaou, Corinne Fasquelle, Benoit Charloteaux, Latifa Karim, Benoit Hennuy, Pierre Frères, Joëlle Collignon, Meriem Boukerroucha, Hélène Schroeder, Fabrice Olivier, Véronique Jossa, Guy Jerusalem, Vincent Bours and Claire Josse.
European Conference of Human Genetics (ESHG). 2017
A miRNA expression based diagnostic tool for breast cancer using random forests.
Stephane Wenric, Pierre Freres, Claire Josse, Vincent Bours, Guy Jerusalem
Benelux Bioinformatics Conference. 2013
Exome sequencing of tumors: relevance in copy-number alteration (CNA) analysis and fixed tissue samples.
Stéphane Wenric, Claire Josse, Corinne Fasquelle, Christophe Poulet, Tiberio Sticca, Meriem Boukerroucha, Guy Jerusalem, Vincent Bours
Belgian Society of Human Genetics Annual Meeting. 2013